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Patients rated symptoms of pruritus, number and maximum size of wheals twice daily.Please see package insert for additional information and possible updates.The clinical significance of these findings is unknown.In laboratory animals, no anticholinergic or alpha1-adrenergic blocking effects were observed.Dosage - Oral: Children 6-11 years: 30 mg twice daily Children /= 6 years and Adults: 10 mg once daily Elderly: Peak plasma levels are increased; elimination half-life is slightly increased; specific dosing adjustments are not available Dosage adjustment in renal impairment: Clcr /= 6 years and Adults: 10 mg every other day Supplied Syrup (Claritin®): 1 mg/m L (120 m L) [contains sodium benzoate; fruit flavor] Tablet (Alavert™, Claritin®, Claritin® Hives Relief; Tavist® ND): 10 mg Tablet, rapidly-disintegrating: 10 mg Alavert™: 10 mg [contains phenylalanine 8.4 mg/tablet] Claritin® Redi Tabs®: 10 mg [mint flavor] Dimetapp® Children's ND: 10 mg [contains phenylalanine 8.4 mg/tablet] (pseudoephedrine 120mg fexofenadine 60mg).Dosing:: one tablet twice daily for adults and children 12 years of age and older (should be taken on an empty stomach).

Mechanism of Action Cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative effects.

Sustained-release: 8 or 12 mg po every 8 to 12 hours. Supplied: Extended Release Cap: 6 mg, 8 mg, 12 mg Liquid/syrup: 2 mg/5 ml Tablet: 2 mg, 4 mg.

Chewable: 2 mg EExtended Release tab: 8 mg, 12 mg, 16 mg Tavist 12 Hour Allergy Tablets: Clemastine fumarate, USP 1.34 mg (equivalent to 1 mg clemastine).

Moreover, no sedative or other central nervous system effects were observed.

Radiolabeled tissue distribution studies in rats indicated that fexofenadine does not cross the blood-brain barrier.